West Nile Virus as a model for exotic pathogens transmitted by endemic vectors
West Nile virus (WNV) infection is a mosquito-borne zoonosis that is endemo-epidemic in Europe, affecting several countries in southern, eastern and western Europe. WNV incidence is increasing in Europe and its presence is expanding into new areas where it had never been observed before, becoming a global public health concern.
The virus is transmitted among host birds mainly via the bite of infected mosquitoes and incidentally, humans and other mammals may become infected. A number of abiotic (environmental) and biotic factors are known to determine its transmission dynamics.
Temperatures have been reported as one of the important environmental drivers influencing WNV transmission in suitable habitats in Europe as it affects either mosquito breeding success and the extrinsic incubation of the virus.
In face of climatic change, anomalous summer temperatures are considered among the factors affecting the incidence rate and the emergence of the virus into new areas, often associated with new cases in Europe.
Following the analysis of the needs expressed by Public Health and Veterinary Health practitioners from five different countries, MOOD is now working on the WNV case study, as a model for exotic pathogens transmitted by endemic vectors. Leading research experts, Public Health representatives (end-users), data and computer scientists and web developers are joining forces over the next two years to design and develop sustainable Epidemic Intelligence tools that will enhance preparedness and response to current and future WN outbreaks.
Generic tools for event-based surveillance
1a. PadiWeb + ProMED (tbc) connected to visualisation engine (EpiVis)
General tools for risk mapping
PadiWeb + ProMED (to be confirmed) connected to visualisation engine (EpiVis)
- How to better identify relevant OneHealth determinants and determine risk thresholds based on data?
- How to better understand environmental risk in terms of vector distribution, vector abundance, vector capacity of transmission and the lack of competence?
- How to automatize the processing and analysis of environmental data (machine learning) for the risk assessment of vector-borne diseases?
Generic data access module
Data visualisation, query, download (vector, host, environment)
MOOD contacts for WN
Case Study Facilitator
DVM,PhD at Fondazione Edmund Mach – Italy
Risk Map for WN in Europe
Environmental engineer at Spatial Epidemiology Lab, ULB
E.R.G.O. (United Kingdom)
Social Scientist at GERDAL
Veterinary Epidemiologist at CIRAD, France
Activities & Updates
⦁ Review of current PADI-WEB keywords used for WN and output (feasible in February/March)
⦁ Suggestions for improvement by WN experts
⦁ Update/addition of keywords
⦁ Analysis of outputs
⦁ At a later stage: comparison/complementarity: LIRMM visualization versus PADI-WEB outputs
Surveillance officers involved in WN surveillance
MOOD experts involved
Mathieu Roche (CIRAD), Elena Arsevska (CIRAD) Pascale Poncelet (LIRMM)
Mathieu Roche (CIRAD)
Updates from 23-24 June 2022:
- Integration with existing Epidemic Intelligence tools will be taken into account by our developers to improve uptake of the product. The possibility for a national end-user/surveillance practitioner to load his/her own data in an offline version to compare EBS and IBS data would be a relevant feature of the visualization tool to be developed. One important point to keep in mind is that one needs to proceed with caution when using un-confirmed and unstructured event-based surveillance data and that human involvement is an important step in data validation. End users willing to try using Padi-web can send a mail to email@example.com to get access to the platform.
Content validated by Annapaola Rizzoli (FEM), Elena Arsevska (CIRAD), and Fanny Bouyer (GERDAL)